||U.S. Environmental Protection Agency's Guidelines for Mutagenicity Risk Assessment and Some Comments on Aneuploidy.
Dellarco, V. L. ;
Jacobson-Kram, D. ;
||Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Hazardous materials ;
||Some EPA libraries have a fiche copy filed under the call number shown.
The paper describes the risk assessment strategy used by the U.S. Environmental Protection Agency (EPA) to evaluate mutagenic risk. The Agency considers all endpoints relevant to genetic risk. Evaluating and quantifying risk is not a straightforward process and requires many assumptions. The U.S. EPA mutagenicity guidelines should not be regarded as comprehensive or complete, but rather providing a reasonable guide for using toxicological data in assessing genetic risk. Because of the dynamic nature of the area, as new information is gained, the 'Guidelines' will be updated and modified if necessary.