Record Display for the EPA National Library Catalog


Main Title Mutagenicity Assessment of Acetaldehyde.
Author Dellarco, V. L. ;
CORP Author Environmental Protection Agency, Washington, DC. Reproductive Effects Assessment Group.
Year Published 1988
Report Number EPA/600/J-88/001;
Stock Number PB88-169099
Additional Subjects Toxicology ; Acetaldehyde ; Reviews ; Reprints ; Mutagenesis
Library Call Number Additional Info Location Last
NTIS  PB88-169099 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 22p
Acetaldehyde has been shown in studies by several different laboratories to be a clastogen and inducer of sister chromatid exchanges in cultured mammalian cells. Although there have been very few studies in intact mammals, the available evidence suggests that acetaldehyde produces similar cytogenetic effects in vivo. The production of cytogenetic abnormalities may be related to the ability of acetaldehyde to form DNA-DNA and/or DNA-protein cross-links. Acetaldehyde apparently has not been evaluated for its ability to cause gene mutations in cultured mammalian cells, but has been shown to produce sex-linked recessive lethals in Drosophila. In general, bacterial tests have been negative. Although acetaldehyde is a genotoxic cross-linking agent, it does not appear to cause DNA strand breaks. There were no studies available regarding the potential of acetaldehyde to produce genetic damage in mammalian germ cells in vivo.