Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Development of Locomotor Activity of Rat Pups in Figure-Eight Mazes.
Author Ruppert, P. H. ; Dean, K. F. ; Reiter, L. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/109;
Stock Number PB85-244309
Additional Subjects Maze learning ; Rats ; Laboratory animals ; Social factors ; Experiential factors ; Reprints ; Locomotor activity
Library Call Number Additional Info Location Last
NTIS  PB85-244309 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 16p
In a series of four experiments, social and experiential factors that influence the development of motor activity in rat pups were examined. Motor activity was monitored from postnatal days 13 to 21 as photocell interruptions in figure-eight mazes and comparisons were made between (1) pups maintained in a next box containing a dam and siblings and allowed access to the maze for 23 hr/day, (2) pups tested daily for 1 hr/day vs. pups tested only on postnatal days 15, 18, or 21, (3) pups tested daily for either 5 min, 30 min, or 1 hr/day, and (4) pups tested daily for 30 min/day either singly in a maze, paired with a littermate, or paired with an anesthetized pup of the same age. A monotonic increase in activity was seen for nest-box testing, minimal developmental change was seen for pups tested on only a single day or for pups tested with an anesthetized pup, whereas all other groups showed an inverted U-shaped profile of activity which was influenced by the duration of testing and/or the presence of a littermate. These data emphasize the relevance of environmental factors as determinants of preweaning behavior.