Record Display for the EPA National Library Catalog


Main Title Effects of Phosgene Exposure on Bacterial, Viral, and Neoplastic Lung Disease Susceptibility in Mice.
Author Selgrade, M. K. ; Starnes, D. M. ; Illing, J. W. ; Daniels, M. J. ; Graham., J. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/225;
Stock Number PB90-146051
Additional Subjects Respiratory diseases ; Phosgene ; Lung neoplasms ; Influenza ; Exposure ; Mice ; Mortality ; Models ; Graphs(Charts) ; Infectious diseases ; Cells(Biology) ; Reprints ; Immune response ; Disease susceptibility ; Air pollution effects(Animals) ; Streptococcus zooepidimicus ; Dose-response relationships ; Virus diseases ; B16 melanoma ; Phagocytosis ; Bacterial infections
Library Call Number Additional Info Location Last
NTIS  PB90-146051 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 19p
The effects of phosgene inhalation exposure on host resistance models representative of bacterial, viral, and neoplastic lung diseases were assessed. A single 4 h exposure to concentrations of phosgene of 0.025 ppm and above significantly enhanced mortality due to aerosol infection with Streptococcus zooepidimicus and significantly increased the number of B16 melanoma tumors which developed in the lungs of mice following intravenous inoculation of syngeneic tumor cells. In contrast, 5 daily 4 h exposures to 0.5 ppm phosgene did not affect mortality following infection with influenza virus. Bacteria recovered from lavage fluid of mice exposed to 0.05 ppm for 4 h increased between 3 and 48 h post infection while bacteria recovered from lavage fluid of air-exposed mice declined to nearly undetectable levels. The data indicate that exposure to phosgene concentrations equal to 1-25% of the current TLV (0.1 ppm) significantly enhanced susceptibility to bacterial and tumor disease in mice. (Copyright (c) 1989 by Hemisphere Publishing Corporation.)