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Main Title Effects of NiCl2 and CdCl2 on Susceptibility to Murine Cytomegalovirus and Virus-Augmented Natural Killer Cell and Interferon Responses.
Author Daniels, M. J. ; Menache, M. G. ; Burleson, G. R. ; Graham, J. A. ; Selgrade, M. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/J-87/121;
Stock Number PB88-144472
Additional Subjects Nickel ; Cadmium ; Immunology ; Toxicity ; Viral diseases ; Infectious diseases ; Immunity ; Laboratory animals ; Mice ; Reprints ; Immune reactions ; Toxic substances ; Cytomegaloviruses ; Killer cells(Natural) ; Interferon inducers
Library Call Number Additional Info Location Last
NTIS  PB88-144472 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Female C3H/HeJ or CD-1 mice were infected with a sublethal dose of murine cytomegalovirus (MCMV) and then exposed to nickel chloride NiCl2 or cadmium chloride (CdCl2), intramuscularly (im) or by inhalation. Effects of these treatments on disease susceptibility, virus-augmented and spontaneous natural killer (NK) cell activity, and virus induction of interferon (IFN) were determined. NiCl2 (20 mg/kg, im) enhanced mortality due to MCMV in both mouse strains, and a reduction in virus augmented NK cell activity was seen at doses as low as 10 mg NiCl2/kg (im). At 6.25 mg CdCl2/kg (im) there was a significant depression of NK cell activity, but there was no effect on mortality due to infection. Effects on NK activity did not appear to be due to effects on IFN production since neither of the metal treatments caused depression of the response. Neither metal had any effect on these parameters when given by inhalation. (Copyright (c) 1987 by the Society of Toxicology.)