Record Display for the EPA National Library Catalog


Main Title Murine Cytomegalovirus Host Resistance Models.
Author Selgrade, M. J. K. ; Daniels, M. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Publisher 1992
Year Published 1992
Report Number EPA/600/A-92/165;
Stock Number PB92-217025
Additional Subjects Cytomegaloviruses ; Immunology ; Neutralization tests ; Virus replication ; Mice ; Animal disease models ; Natural killer cells ; Immunosuppression ; Plaque assay ; Liver ; Cytotoxic T-lymphocytes ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB92-217025 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 30p
Mouse cytomegalovirus (MCMV) is a well developed and extremely useful and relevant host resistance model for immunotoxicity testing. Rat cytomegalovirus (RCMV) is currently under development and may have similar applications. Cytomegaloviruses are species specific; RCMV is a distinct virus from MCMV and both are distinct from human cytomegalovirus (HCMV). However, biologic and biophysical similarities between these viruses make the animal viruses good models for the human infection. The chapter discusses the rationale for using MCMV as a host resistance model, provides some representative data, and gives detailed information on methods needed to apply the model. Background on RCMV is also presented along with detailed methods (to the extent available) for applying the RCMV model are also provided.