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Main Title Influence of Cadmium, Nickel, and Chromium on Primary Immunity in Mice.
Author Graham, J. A. ; Miller, F. J. ; Daniels, M. J. ; Payne, E. A. ; Gardner, D. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC
Year Published 1977
Report Number EPA/600/J-78/045;
Stock Number PB-287 137
Additional Subjects Cadmium ; Metals ; Immunity ; Nickel ; Chromium ; Toxicology ; Aerosols ; Inhalation ; Physiological effects ; Mice ; Laboratory animals ; Experimental data ; Concentration(Composition) ; Responses ; Dosage ; Lung ; Exposure ; Nickel oxides ; Reprints ; Humoral immunity ; Hemolytic plaque technique ; Nickel chlorides ; Chromium chlorides ; Cadmium chlorides ; Heavy metals ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB-287 137 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
The effects of metals on the primary humoral immune system of mice were investigated using a hemolytic plaque technique to determine the number of specific antibody-producing spleen cells. Inhalation of NiCl2 for 2 hr resulted in a significant negative linear dose response, the lowest effective concentration tested being 250 micrograms of Ni/cu m. Following a 2 hr aerosol exposure to NiCl2, the lung cleared Ni on a first-order kinetics basis. A significant reduction in the number of plaques per 10 to the 6th power cells was also observed with exposure to 190 micrograms of Cd/cu m. Analyses of the data from intra-muscularly exposed mice indicated that concentrations greater than or equal to 3.90 micrograms of Ni/g body weight (as NiSO4) and greater than or equal to 9.25 micrograms of Ni/g body weight (as NiCl2) resulted in significant immunosuppression. Intramuscular treatments with NiO, CdCl2, and CrCl3 had no effect at the concentrations tested.