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Main Title Correlation between Chemical Suppression of Natural Killer Cell Activity in Mice and Susceptibility to Cytomegalovirus: Rationale for Applying Murine Cytomegalovirus as a Host Resistance Model and for Interpreting Immunotoxicity Testing in Terms of Risk of Disease.
Author Selgrade, M. K. ; Daniels, M. J. ; Dean, J. H. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;Sterling Research Group, Rensselaer, NY. Drug Safety Assessment.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/444;
Stock Number PB93-141430
Additional Subjects Natural killer cells ; Cytomegalic inclusion disease ; Toxicology ; Immunosuppressive agents ; Immunosuppression ; Mice ; In vivo analysis ; Biological models ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB93-141430 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 16p
The purpose of the study was to determine the relationship between chemical suppression of natural killer (NK) cell activity in mice and chemical effects on susceptibility to murine cytomegalovirus (MCMV) infection. Data from studies with 8 chemicals administered in various doses and by various routes were evaluated, and a statistically significant correlation was observed between chemical suppression of virus-augmented NK cell activity and increased mortality due to MCMV infection. In contrast, effects of the same chemical treatments on spontaneous NK cell activity (i.e., NK cell activity in uninfected mice) did not correlate with effects of these chemicals on mortality due to MCMV.