Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Septotemporal Gradients of Trimethyltin-Induced Hippocampal Lesions.
Author Chang, L. W. ; Dyer, R. S. ;
CORP Author Arkansas Univ. for Medical Sciences, Little Rock.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/161;
Stock Number PB86-100583
Additional Subjects Toxicology ; Rats ; Reprints ; Tin/trimethyl ; Hippocampus
Library Call Number Additional Info Location Last
NTIS  PB86-100583 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 8p
Rats were administered 6 mg/kg trimethyltin (TMT) PO, and sacrificed at various time points (up to 60 days) for pathological evaluation. Studies along the full extent of the septotemporal axia revealed region-specific and cell field-specific damage. Dentate granule cells were most affected at the temporal pole and were only minimally affected at the septal pole. CA3c pyramidal neurons were affected along the full extent of the septotemporal axis. CA3a and CA3b pyramid cells were most affected in the septal pole, and virtually unaffected in the temporal pole. It is suggested that CA3a and CA3b pyramidal cell damage may be dependent upon functionally intact granule cells.