Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Macrophysiological Assessment of Organometal Neurotoxicity.
Author Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/D-85/271;
Stock Number PB86-128576
Additional Subjects Toxicology ; Organometallic compounds ; Organomercurials ; Organotins ; Macrophysiology ; Neurotoxicity
Library Call Number Additional Info Location Last
NTIS  PB86-128576 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 110p
Neurophysiological methods fall into two broad categories, macrophysiological and microphysiological. The unit of analysis for microphysiological methods is cellular or subcellular (e.g. membrane or channel) whereas the unit of analysis for macrophysiological methods is a population of neurons. Each set of methods may be used to great advantage or disadvantage, depending upon the experimental question at hand. The purpose of the chapter is to focus on studies which have used macrophysiological methods to investigate the neurotoxicity produced by organometals. For each study to be discussed, the issues under consideration will be (1) appropriateness of the method to answer the experimental question; (2) adequacy of experimental design in using the method; (3) importance of the findings; and (4) identification of unresolved issues.