| Main Title |
Species and Strain Comparison of Acute Neurotoxic Effects of Trimethyltin in Mice and Rats. |
| Author |
Chang, L. W. ;
Wenger, G. R. ;
McMillan, D. E. ;
Dyer, R. S. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1983 |
| Report Number |
EPA/600/J-83-049; |
| Stock Number |
PB84-101260 |
| Additional Subjects |
Toxicology ;
Central nervous system ;
Pathology ;
Comparison ;
Mice ;
Rats ;
Laboratory animals ;
Dosage ;
Reprints ;
Tin/trimethyl ;
Neurotoxicity
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-101260 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
17p |
| Abstract |
Pathological changes in the central nervous system in two strains of mice (BALB/c and C57BL/6) and two strains of rats as a result of trimethyltin (TMT) intoxication were compared. Both strains of mice were administered with trimethyltin chloride at a dosage of 3.0 mg TMT-C1/kg b.w. while both strains of rats were exposed to 7.5mg TMT-C1/kg b.w. Animals were sacrified at the time of development of observable neurological signs (tremor, aggression): 2 days for both strains of mice, 3 days for Long Evans (LE) rats, and 5 days for Sprague Dawley (SD) rats. It was found that there were both species and strain differences in TMT toxicity. |
