Record Display for the EPA National Library Catalog


Main Title Acute Behavioral Toxicity of Sulfolane: Influence of Hypothermia.
Author Ruppert, P. H. ; Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/278;
Stock Number PB86-159993
Additional Subjects Solvents ; Hypothermia ; Toxicology ; Oxygen consumption ; Behavior ; Rats ; Laboratory animals ; Reprints ; Sulfolane
Library Call Number Additional Info Location Last
NTIS  PB86-159993 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Sulfolane is a solvent which produces hypothermia and decreased oxygen consumption following acute exposure. In the present experiment, the author investigated effects of sulfolane on a behavioral measure of toxicity at ambient temperatures which would either prevent or facilitate the development of hypothermia. Adult, male Long Evans rats (N=10/dose) received a single i.p. injection of saline, 200, 400 or 800 mg/kg sulfolane. Motor activity in figure-eight mazes was assessed 1 hr after dosing in testing rooms maintained at either 20.8 C or at 32.3 C. At the warm ambient temperature, sulfolane produced hypoactivity but not hypothermia. At the cooler temperature, sulfolane-induced hypoactivity was more pronounced, and rats were hypothermic. Therefore, a behavioral change could be detected at sublethal dosages of sulfolane in the absence of hypothermia.