Record Display for the EPA National Library Catalog


Main Title Trimethyltin Reduces Recurrent Inhibition in Rats.
Author Dyer, R. S. ; Boyes, W. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/257;
Stock Number PB85-192946
Additional Subjects Toxicity ; Inhibition ; Rats ; Trimethyltin compounds ; Neurotoxins ; Electric stimulation ; Recurrence
Library Call Number Additional Info Location Last
NTIS  PB85-192946 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 5p
Rats with electrodes chronically implanted in the perforant path for electrical stimulation, and dentate gyrus for recording were treated with a single oral administration of either saline, 5 mg/kg trimethyltin (TMT) or 6 mg/kg TMT. Recurrent inhibition was assessed by paired pulse activation of the perforant path input to the dentate gyrus. The measure of recurrent inhibition employed was the ratio of the population spike amplitudes of the responses to the first and second of the paired stimuli. Inhibition was assessed immediately before, and at 2, 24 and 120 hrs following TMT. The results indicated a reduction in inhibition as early as 2 hr following treatment, suggesting that TMT-induced destruction of hippocampal pyramidal cells may be secondary to their over-activation from an uninhibited mossy fiber system.