Record Display for the EPA National Library Catalog


Main Title Possible Role of the Brainstem in the Mediation of Prepulse Inhibition in the Rat (Journal Version).
Author Saitoh, K. ; Tilson, H. A. ; Shaw, S. ; Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Publisher c1987
Year Published 1987
Report Number EPA/600/J-87/411;
Stock Number PB89-105571
Additional Subjects Brain stem ; Startle reaction ; Acoustic stimulation ; Laboratory animals ; Electric stimulation ; Reprints ; Cuneiform nucleus ; Prepulse inhibition
Library Call Number Additional Info Location Last
NTIS  PB89-105571 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Bilateral stimulation of electrodes aimed at the cuneiform nucleus produced significant inhibition of the startle response produced by presentation of an 8 KHz, 110 dB tone. Stimulation of electrodes aimed at the deep mesencephalic nucleus also reduced the magnitude of the startle response, but the effect was less than that following stimulation sites near the cuneiform nucleus. Histological reconstruction of the electrode tip locations revealed a significant negative correlation between the maximum magnitude reduction of the acoustic startle response following an electrical prepulse stimulus and the distance from the cuneiform nucleus. Histological examination also indicated that some electrodes aimed at the cuneiform nucleus were located in or near the inferior colliculus or parabrachial nucleus, all of which are thought to be part of an inhibitory circuit parallel to the acoustic startle reflex arc. These experiments support the view that the prepulse inhibition of the acoustic startle reflex originates in the brainstem. (Copyright (c) 1987 Elsevier Scientific Publishers Ireland Ltd.)