Record Display for the EPA National Library Catalog


Main Title Neurophysiological Consequences of Acute Exposure to Methylpyridines.
Author Dyer, R. S. ; Burdette, L. J. ; Janssen, R. ; Boyes, W. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/265;
Stock Number PB86-158581
Additional Subjects Toxicology ; Bioassay ; Rats ; Laboratory animals ; Dosage ; Reprints ; Pyridines/methyl ; Evoked responses
Library Call Number Additional Info Location Last
NTIS  PB86-158581 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 16p
A series of neurophysiological tests was performed on Long-Evans hooded rats treated with either 2-, 3- or 4-methylpyridine at dosages of 100mg/kg, approximately 1/2 the i.p. LD50. The tests contained measures of sensory function (paired pluse flash evoked potentials, pattern reversal evoked potentials, brainstem auditory evoked responses) and cerebral excitability (pentylenetetrazol (PTZ) seizures and hippocampal afterdischarges). In general, rats treated with 2- and 3-methylpyridine were more affected than those treated with 4-methylpyridine. The changes observed were in many ways similar to those seen following administration of depressant compounds: increased latency of evoked potentials and increased latency to PTZ seizures. Not all findings, however, were consistent with previously observed patterns of CNS depression.