Record Display for the EPA National Library Catalog


Main Title Convulsant Properties of Cyclotrimethylenetrinitramine (RDX): Spontaneous, Audiogenic, and Amygdaloid Kindled Seizure Activity (Journal Version).
Author Burdette, L. J. ; Cook, L. L. ; Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Graduate Hospital, Philadelphia, PA. Dept. of Neurology.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/092;
Stock Number PB89-109631
Additional Subjects RDX ; Toxicity ; Laboratory animals ; Explosives ; Amygdala ; Limbic system ; Reprints ; Convulsants ; Dose-response relationships ; Kindling(Neurology)
Library Call Number Additional Info Location Last
NTIS  PB89-109631 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Dose-effect and time course relationships were determined for the effects of cyclotrimethylemetrinitramine (RDX) on seizure susceptibility. Male Long Evans rats treated with 0-60 mg/kg RDX, p.o., were monitored for spontaneous seizures during an 8 h interval between dosing and audiogenic (AG) seizure testing. Spontaneous and AG seizures were observed at dosages as low as 10-12.5 mg/kg. Spontaneous seizure incidence peaked at 2 h for all RDX treatment groups. In contrast, AG seizures (37.5 mg/kg) could be elicited only at 8 and 16 h, despite significant elevation of plasma RDX concentrations at 2 and 4 h. Because limbic system involvement was suggested by spontaneous seizure characteristics, the rate of amygdaloid kindling was measured following daily treatment with 6.0 mg/kg. The dosage significantly accelerated kindling development without inducing spontaneous seizures or producing an accumulation of RDX in plasma. These data provide preliminary evidence that limbic structures may participate in RDX induced seizure susceptibility. (Copyright (c) 1988 by Academic Press, Inc.)