Record Display for the EPA National Library Catalog


Main Title Chlordimeform Produces Profound, Selective, and Transient Changes in Visual Evoked Potentials of Hooded Rats.
Author Boyes, W. K. ; Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/258;
Stock Number PB85-192961
Additional Subjects Toxicity ; Pesticides ; Insecticides ; Acaricides ; Chlorine organic compounds ; Visual perception ; Rats ; Laboratory animals ; Formamidines ; Chlordimeform ; Dose rate ; Electric stimulation
Library Call Number Additional Info Location Last
NTIS  PB85-192961 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 17p
Rat visual function was tested after acute exposure to chlordimeform (CDM), a formamidine insecticide/acaricide. Adult male Long-Evans rats were surgically implanted with epidural recording electrodes overlying visual cortex and tested 1 week later. Pattern reversal-evoked potentials (PREPs), flash-evoked potentials (FEPs), and FEP recovery ratios were measured after acute CDM administration. In the first study, which examined dose-response relationships, i.p. injections of 0 (saline), 5, 15, or 40 mg/kg CDM-HCl were administered 30 min prior to testing. In the second study, which examined the time course of CDM action, PREPs and paired-pulse FEPs were recorded 3, 6, and 24 h after dosage with either 0 or 40 mg/kg CDM. In summary, acute exposure to CDM temporarily increased both the amplitude and latency of PREPs, but only the latency of FEPs.