Record Display for the EPA National Library Catalog


Main Title Chlordimeform Produces Contrast-Dependent Changes in Visual Evoked Potentials of Hooded Rats.
Author Boyes, W. K. ; Jenkins, D. E. ; Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/160;
Stock Number PB86-101136
Additional Subjects Insecticides ; Exposure ; Rats ; Laboratory animals ; Reprints ; Evoked responses ; Chlordimeform
Library Call Number Additional Info Location Last
NTIS  PB86-101136 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 19p
Acute exposure to the insecticide/acaricide chlordimeform (CDM) produces large, selective and transient changes in visual evoked potentials of rats. Experiments were conducted investigating the influence of physical characteristics of the evoking stimuli on the CDM effect. Adult male Long-Evans rats with epidural visual cortex electrodes were used. In Experiment 1, several alternating square wave grating pattern sizes were used to elicit pattern reversal evoked potentials (PREPs). In Experiment 2, PREPs were elicited with gratings oriented at 0 (horizontal), 45, 90, or 135 degrees. Treatment with 40 mg/kg CDM increased PREP amplitudes and latencies regardless of orientation. In Experiment 3, flash evoked potentials (FEPs), elicited with strobe flashes spanning four log units of intensity, showed a small but significant CDM does X intensity interaction on P2N2 peak-to-peak amplitude.