Record Display for the EPA National Library Catalog


Main Title Biochemical and Biological Markers: Implications for Epidemiologic Studies.
Author Griffith, J. ; Duncan, R. C. ; Hulka., B. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Miami Univ., FL. School of Medicine. ;North Carolina Univ. at Chapel Hill. Dept. of Epidemiology.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/456;
Stock Number PB91-109488
Additional Subjects Epidemiology ; Exposure ; Industrial medicine ; Toxicity ; Hazardous materials ; Research design ; Biochemical markers ; Biological markers ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB91-109488 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Given that a major task for environmental epidemiology is to provide evidence of long-term health risks early enough so that appropriate preventive measures can be taken, biochemical and biological markers of potentially harmful environmental exposures are of great interest and possibly of great value. Such markers are in two discrete classes, those quantitatively related to exposure itself, reflecting the magnitude of such exposures or of the body burden of the pollutants, and those markers which reflect the biological response to such exposures. This paper suggests guidelines for the appropriate use of cross-sectional, retrospective, and prospective designs in epidemiologic investigations of markers of exposure and disease. Also presented are suggestions for the application of sensitivity, specificity, reliability, and acceptability in marker studies since the effectiveness of any marker will ultimately be judged on these characteristics.