| Main Title |
Health effects of fine- and coarse-mode particulate matter : exposures by inhalation and intratracheal instillation / |
| Author |
Aranyi, C. ;
Drummond, J. ;
Ehrlich, R. ;
Fenters, J. D. ;
Graf, J.
|
| Other Authors |
|
| CORP Author |
IIT Research Inst., Chicago, IL.;Health Effects Research Lab., Research Triangle Park, NC. ;International Research and Development Corp., Mattawan, MI. |
| Publisher |
U.S. Environmental Protection Agency, Health Effects Research Laboratory, |
| Year Published |
1984 |
| Report Number |
EPA 600-D-84-111; EPA-R-806327 |
| Stock Number |
PB84-201656 |
| OCLC Number |
12645448 |
| Subjects |
Air--Pollution--Physiological effect
|
| Additional Subjects |
Toxicology ;
Inhalation ;
Aerosols ;
Air pollution effects(Animals) ;
Particulates
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD ARCHIVE |
EPA 600-D-84-111 |
In Binder |
Headquarters Library/Washington,DC |
07/12/2017 |
| EJBD |
EPA 600-D-84-111 |
|
Headquarters Library/Washington,DC |
01/09/2020 |
| ELBD |
EPA 600-D-84-111 |
|
AWBERC Library/Cincinnati,OH |
04/10/1998 |
| NTIS |
PB84-201656 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
3 pages ; 28 cm |
| Abstract |
Because coarse mode particles are rarely studied in their existing size ranges (greatest mass about 5-7 micrometers, aerodynamic diameter), the authors investigate the effects of four such particles, quartz, ferric oxide, calcium carbonate, and sodium feldspar, on host defenses against bacterial pulmonary infection. Mice which received intratracheal instillations of 10, 33, and 100 micrograms/mouse were exposed within an hour to aerosols of viable Streptococcus, and pneumonia-induced mortality was measured. At 33 and 100 micrograms/mouse, all particles significantly increased mortality. At the lower dose, only Fe203 caused a significantly increase in mortality. To evaluate potential delayed effects, mice were challenged with the bacteria 24 h after exposure to 100 micrograms particles/mouse. Delaying the challenge did not significantly alter the response, except for the sodium feldspar group for which a partial recovery was observed. |
| Notes |
Caption title. At head of title: Environmental research brief. "May 1984." "EPA 600-D-84-111." |
