Record Display for the EPA National Library Catalog


Main Title Effects of Inhaled Phosgene on Rat Lung Antioxidant Systems.
Author Jaskot, R. H. ; Grose, E. C. ; Richards, J. H. ; Doerfler, D. L. ;
CORP Author ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1991
Year Published 1991
Report Number EPA-68-02-4450; EPA/600/J-93/395;
Stock Number PB93-236321
Additional Subjects Antioxidants ; Lung ; Phosgene ; Air pollution effects(Animals) ; Glucosephosphate dehydrogenase ; Rats ; Glutathione peroxidase ; Glutathione reductase ; Superoxide dismutase ; Dose-response relationships ; Graphs(Charts) ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB93-236321 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
A concentration-response and concentration x time (CxT) study were undertaken to determine the effect of phosgene (COCl2) inhalation on pulmonary antioxidant processes as determined by changes in endogenous glutathione (GSH) and antioxidant-associated enzymes (GSH peroxidase, GSH reductase, glucose-6-phosphate dehydrogenase, and superoxide dismutase). Rats were exposed to 0.0, 0.1, 0.25, 0.5, and 1.0 ppm phosgene for 4 hr and 0.25 ppm phosgene for 8 hr. The endpoints were assayed at 0, 1, 2, 3 and 7 days after exposure cessation. The lowest effective concentration was 0.1 ppm phosgene (increases in measured variables from 8 to 35% above control values). At all concentrations, major effects were observed 1 to 2 days after exposure (12 to 159% above control), peaking at 2 to 3 days postexposure (11 to 253% above control), and in some cases were still evident 7 days (10 to 65% above control) after exposure. The CxT study using the same dose (120 ppm-min), but different times and concentration (0.25 ppm for 8 hr and 0.5 ppm for 4 hr), showed a concentration dependence. The peak antioxidant enzyme changes observed for the higher concentration (0.5 ppm) were at least double those observed for the lower concentration (0.25 ppm). (Copyright (c) 1991 Society of Toxicology.)