||Health and environmental effects profile for pentachloronitrobenzene /
Choudhury, H. ;
Coleman, J. ;
Mink, F. L. ;
De Rosa, C. T. ;
Stara, J. F.
||Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office.;Syracuse Research Corp., NY. Center for Chemical Hazard Assessment.
|| Environmental Protection Agency, Office of Research and Development, Environmental Criteria and Assessment Office,
Hazardous wastes--Environmental aspects. ;
Hazardous materials ;
Chlorine organic compounds ;
Nitro compounds ;
Laboratory animals ;
Health effects ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||66 pages ; 28 cm
Pure pentachloronitrobenzene (PCNB) is a colorless crystalline solid; the primary usage is as a soil fungicide for a wide variety of crops and in seed treatment. The fate of PCNB in water has not been comprehensively studied. Pertinent data regarding the fate and transport of PCNB in air or levels in ambient and drinking water could not be located. PCNB is persistent in soils; volatilization and biodegradation are important processes in the loss from soils. Although the evidence indicates that relatively pure PCNB did not induce hepatomas in B6C3F1 mice, albino Swiss female mice fed relatively pure PCNB with HCB contamination of 2.7% developed statistically significant increased incidences of subcutaneous fibromas and fibrocarcomas. From these data a q1 for humans of 3.93x0.01(mg/kg/day) was derived. The limited evidence in animals and lack of evidence in humans indicate that PCNB is an EPA Group C chemical. Therefore, PCNB has a LOW hazard ranking under CERCLA. A RQ of 1000 was derived based on liver pathology in dogs.
"PB89-201883." "EPA/600/J-87/476." Includes bibliographical references. "Journal article published in Toxicology and Industrial Health, 3(1):5-69(1987)." Microfiche.