The report is a chemical specific manual for hydrogen fluoride (HF). It summarizes information to aid regulators and industry personnel in identifying and controlling release hazards associated with HF. Reducing the risk associated with accidental release of HF involves identifying some of the potential causes of accidental releases that apply to the process facilities that handle and store HF. It identifies examples of potential causes and measures that may be taken to reduce the accidental release risk. Such measures include recommendations on plant design practices; prevention, protection, and mitigation technologies; and operation and maintenance practices. Conceptual cost estimates of example prevention, protection, and mitigation measures are provided. Interest in reducing the probability and consequences of accidental toxic chemical releases that might harm workers within a process facility and people in the surrounding community prompted the preparation of a series of technical manuals addressing accidental releases of toxic chemicals.