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Main Title Effects of environmental contaminants on cell mediated immunity /
Author Koller, Loren D.,
Other Authors
Author Title of a Work
Environmental health effects research series
EPA-600/1-78-071. United States.
CORP Author Oregon State University. School of Veterinary Medicine.; Health Effects Research Laboratory (Cincinnati, Ohio)
Publisher Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1978
Report Number EPA-600/1-78-071; EPA-R-804200
Stock Number PB-292 034
OCLC Number 04697666
ISBN pbk.
Subjects Cellular immunity ; Lead--Physiological effect ; Cadmium ; Immunity, Cellular ; cadmium (metal)
Additional Subjects Cellular immunity ; Lead--Physiological effects ; Cadmium ; Immunity ; Lead(Metal) ; Toxicology ; Immunology ; Recommendations ; Mice ; Laboratory animals ; Experimental data ; Diets ; Ingestion(Biology) ; Spleen ; Lymphocytes ; Age ; Toxicity ; Contaminants ; Cellular immunity ; Immune responses ; Drinking water ; Phagocytosis ; Toxic substances
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJED  EPA 600/1-78-071 OCSPP Chemical Library/Washington,DC 01/01/1988
EKBD  EPA-600/1-78-071 Research Triangle Park Library/RTP, NC 06/30/2000
ELBD ARCHIVE EPA 600-1-78-071 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
NTIS  PB-292 034 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation vi, 27 pages ; 28 cm
The effect of lead and cadmium on cell-mediated immunity was studied in peritoneal macrophages, B-, and T-lymphocytes of mice. Lead and cadmium were administered in drinking water for 10 weeks in short-term experiments and up to 18 months to deal with immune responses in aged mice. Lead and cadmium both tended to stimulate phagocytosis in peritoneal macrophages. Consequently, depressed humoral immune response could not be explained on the basis of an effect on the macrophage. The splenic B-lymphocyte response was depressed by both lead and cadmium treatment. The direct effect of these metals on B cells could account at least in part, for the suppression of the humoral immune response reported in previous studies. In long-term studies in aged mice low doses of lead (13 mg/l) tended to stimulate certain immune responses. Results obtained with higher doses (up to 1300 mg/l) were complicated by a natural immunosuppression in aged mice. As a consequence, no significant alterations were observed with high doses and the impact of Pb on the immune system in the long term cannot be predicted on the basis of this limited experimentation.
"December 1978." "Grant No. R 804200." "Project Officer Richard J. Bull, Toxicological Assessment Branch." "School of Veterinary Medicine, Oregon State University." Includes bibliographical references (pages 25-27).