Record Display for the EPA National Library Catalog


Main Title Developmental Effects of Methyl Benzimidazolecarbamate Following Exposure during Early Pregnancy.
Author Cummings, A. M. ; Ebron-McCoy, M. T. ; Rogers, J. M. ; Barbee, B. D. ;
CORP Author ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div.
Publisher c1992
Year Published 1992
Report Number EPA-68-02-4450; EPA/600/J-92/116;
Stock Number PB92-164862
Additional Subjects Teratogenic compounds ; Pregnancy ; Fungicides ; Benomyl ; Dose-response relationships ; Embryos ; Ovum implantation ; Mortality ; Fetus ; Reprints ; Methyl benzimidazolecarbamate
Library Call Number Additional Info Location Last
NTIS  PB92-164862 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Methyl 2-benzimidazolecarbamate (MBC) and its parent compound benomyl are used as agricultural fungicides. Both chemicals are embryotoxic if administered during organogenesis, and benomyl is teratogenic. Rats were administered MBC at 0, 100, 200, 400, or 600 mg/kg/day during Days 1-8 of pregnancy and killed on Day 11 or Day 20 of gestation. On Day 11, embryos were assessed for survival rate, growth parameters, and anomalies. On Day 20, standard developmental toxicity evaluations were performed. Doses of 200 to 600 mg/kg/day MBC reduced embryonic survival by Day 11; exposure to MBC at 100 to 600 mg/kg/day reduced the number of fetuses surviving on Day 20. Evidence of developmental delay was apparent on Day 11 at all doses, and fetal weight was reduced by Day 20.