Record Display for the EPA National Library Catalog


Main Title Role of Steroid Hormones and Decidual Induction in the Regulation of Adenosine Diphosphoribosyl Transferase Activity in Rat Endometrium.
Author Cummings., A. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/210;
Stock Number PB90-146218
Additional Subjects Steroids ; Hormones ; Transferases ; Rats ; Deoxyribonucleic acids ; Estrogens ; Graphs(Charts) ; Enzymes ; Cell nucleus ; Reprints ; Endometrium ; Adenosine diphosphate ribase ; Dose-response relationships ; NAD
Library Call Number Additional Info Location Last
NTIS  PB90-146218 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
To assess the effect of ovarian steroid hormones on enzyme activity, adenosine diphosphoribosyl transferase (ADPRT) was measured in endometrial nuclei isolated on estrus and on d 4 from rats ovariectomized on estrus (d 0) and treated d 0-3 with vehicle, 1 microg estrone/d (E), 1 mg progesterone on d 0 and 2 mg d 1-3 (P), or the 2 hormones combined (E+P). Decidual induction in rats treated with E+P through d 8 demonstrated the ability of the combination treatment to support a decidual response comparable to that of pseudopregnancy. Characteristics of ADPRT were assessed by the determination of assay optima, and the identity of the reaction product as poly(ADP-ribose) was confirmed. Deoxyribonuclease-stimulated activity (total) was higher than non-stimulated ADPRT activity (endogenous) in all assays except on estrus. Estrone treatment produced an increase in ADPRT activity accompanied by increased DNA content, tissue mass, and total protein. (Copyright (c) 1989 The Endocrine Society.)