Record Display for the EPA National Library Catalog


Main Title Auditory Deficits and Motor Dysfunction Following Iminodipropionitrile Administration in the Rat.
Author Crofton, K. M. ; Knight, T. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;North Carolina Central Univ., Durham. Dept. of Biology.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-92/017;
Stock Number PB92-143890
Additional Subjects Animal behavior ; Audiometry ; Motor activity ; Toxicology ; Startle reaction ; Reflexes ; Dose-response relationships ; Body weight ; Reprints ; Iminodipropionitriles
Library Call Number Additional Info Location Last
NTIS  PB92-143890 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
The behavioral effects of 3,3'-iminodipropionitrile (IDPN) were studied using reflex modification of the acoustic startle response and figure-eight maze activity. A number of experiments were conducted with separate groups of adult male Long-Evans hooded rats exposed to saline or 50-500 mg/kg IDPN for 3 consecutive days. Auditory thresholds (reflex modification), motor activity, and grip strength were measured 1 day, and 1, 3, and 9 weeks postdosing. Reflex inhibition was monitored daily, prior to, during, and for 7 days following exposure. Auditory thresholds for 5- and 40-kHz tones were elevated approximately 25 dB and 50 dB, respectively. The onset of the auditory dysfunction in the 200-mg/kg/day group, as demonstrated by a loss of reflex inhibition, was 2 days for the 40-kHz tone and 4 days for the 5-kHz tone. Motor activity was increased up to 400% in the 200-mg/kg group, whereas there was no alteration in hindlimb grip strength. These data demonstrate dosage- and time-dependent alterations in auditory and motor function following IDPN exposure.