Record Display for the EPA National Library Catalog


Main Title Examination of the Proconvulsant Actions of Pyrethroid Insecticides Using Pentylenetetrazol and Amygdala Kindling Seizure Models.
Author Gilbert, M. E. ; Acheson, S. K. ; Mack, C. M. ; Crofton., K. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/136;
Stock Number PB91-109744
Additional Subjects Insecticides ; Toxicology ; Amygdala ; Reprints ; Kindling(Neurology) ; Convulsions ; Pentylenetetrazol ; Motor activitY ; Locomotion ; Cismethrin ; Deltamethrin ; Dose-response relationships ; Electric stimulation
Library Call Number Additional Info Location Last
NTIS  PB91-109744 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 16p
The seizure-inducing properties of two pyrethroids were assessed by pentylenetetrazol (PTZ) seizure models (repeated ip, sprathreshold ip, and iv), and electrical kindling of the amygdala. The efficacy of po versus ip routes of deltamethrin administration was compared using iv-PTZ administration and tests of locomotor activity in a figure-eight maze. The Type I pyrethroid, cismethrin (8 or 15 mg/kg), and the Type II pyrethroid, deltamethrin (6 or 10 mg/kg), were administered daily, 2 hours prior to electrical kindling stimulation. Both pyrethroids facilitated amygdala kindling to a minimal but equivalent degree, but only at dosages that also evoked strong behavioral signs of toxicity. Cismethrin (15 mg/kg, po) produced a 17% reduction in the threshold dosage of ip-PTZ required to induce a seizure, while delaying the onset of generalized seizure activity. Deltamethrin (10 mg/kg, po) failed to alter threshold or latency to seizure onset, but did increase seizure duration. No differences were revealed between po (0,10,15 mg/kg) or ip (0,1,10 mg/kg) administered deltamethrin on thresholds, seizure durations, latencies to myoclonic jerks, or generalized seizure activity following iv-PTZ. (Copyright (c) 1990 by Intox Press, Inc.)