Record Display for the EPA National Library Catalog


Main Title Enhanced Neurotoxicity of 3,3'-Iminodipropionitrile Following Pretreatment with Carbon Tetrachloride in the Rat.
Author Llorens, J. ; Crofton, K. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/270;
Stock Number PB92-113323
Additional Subjects Toxicity ; Nervous system ; Carbon tetrachloride ; Rats ; Animal behavior ; Metabolic activation ; Liver ; Motor activity ; Startle reaction ; Pentobarbital ; Auditory thresholds ; Reprints ; Iminodipropionitriles
Library Call Number Additional Info Location Last
NTIS  PB92-113323 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
The work tested the hypothesis that IDPN must be metabolized by the liver to an active metabolite to become neurotoxic. Thus a reduction in IDPN neurotoxicity would be expected when liver function is compromised. Male Long-Evans rats were given ip injections of saline, 100 (IDPN1) or 200 (IDPN2) mg/kg of IDPN for three days. Half of the animals in each IDPN dose group received corn oil po and the other half 1 g/kg of the hepatotoxicant carbon tetrachloride (CCl4) for three days, starting one day before IDPN administration. Motor activity and acoustic startle response (ASR) were monitored prior to, and 1, 3, 9 and 16 weeks after IDPN exposure. An observational rating score was obtained at 1, 3 and 9 weeks. Auditory thresholds for 5- and 40-kHz tones were estimated by reflex modification procedures at 10 weeks. Animals receiving IDPN2 alone displayed the overt behavioral signs characteristic of IDPN intoxication (postural disturbances, head dyskinesias, backward walking, circling, increased motor activity, and decreased ASR). They also showed weight loss, hyperactivity, a transient rearing deficit, decreased ASR amplitudes and elevated auditory thresholds for low- and high-frequency tones. None of these symptoms were observed in the animals treated with CCl4 alone, and only a mild transient effect on the observational rating score was shown by the IDPN1 alone animals. (Copyright (c) 1991 by Intox Press, Inc.)