Record Display for the EPA National Library Catalog


Main Title Acute Effects of Amitraz on the Acoustic Startle Response and Motor Activity.
Author Crofton, K. M. ; Boncek, V. M. ; Reiter., L. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Northrop Services, Inc., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/468;
Stock Number PB91-115998
Additional Subjects Pesticides ; Animal behavior ; Acoustics ; Body temperature ; Body weight ; Rats ; Mortality ; Reprints ; Amitraz ; Motor activity ; Startle reaction ; Dose-response relationships
Library Call Number Additional Info Location Last
NTIS  PB91-115998 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
To characterize further the behavioral toxicity of amitraz, comparisons were made between the effects of amitraz on motor activity, the acoustic startle response, body temperature, and body weight in male Long-Evans rats. Acute dosage-effect and time-course determinations of motor activity were made using figure-eight mazes. Dosage-effect and time-course determinations for the acoustic startle response were measured using a 13 KHZ, 120 dB(A), 40 ms tone as the eliciting stimulus, at each of three background white-noise levels. Amitraz was administered orally in the vehicle ('Emulphor'+ethanol+saline,d a dosage- and time-dependent decrease in motor activity which lasted from 4 to 96 h post-administration. The effects of amitraz on the acoustic startle response consisted of an increased latency and a decreased amplitude and sensitization. The time-course of effects on the acoustic startle response were more transient (4-24 h) than the effects on motor activity. Amitraz-exposed animals had decreased body weight that did not return to control levels until 120 h (five days) post-administration. (Copyright (c) 1989 Society of Chemical Industry.)