Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Comparative mesothelioma induction in rats by asbestos and non-asbestos mineral fibers : possible correlation with human exposure risk /
Author Coffin, D. L. ; Palekar, L. D. ; Cook, P. M. ; Creason, J. P. ;
CORP Author Northrop Services, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher Northrop Services, Inc.,
Year Published 1988
Report Number PB88250246
Stock Number PB88-250246
OCLC Number 42725407
Subjects Asbestos--Toxicology. ; Asbestos--Physiological effect.
Additional Subjects Toxicity ; Asbestos ; Hazardous materials ; Attapulgite ; Fibers ; Laboratory animals ; Exposure ; Humans ; Correlations ; Survival ; Neoplasms ; Mesothelioma ; Erionite ; Occupational safety and health
Library Call Number Additional Info Location Last
ESAD  PB88-250246 Region 10 Library/Seattle,WA 05/14/2012
NTIS  PB88-250246 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 02/27/2020
Collation 16 p. : ill. ; 28 cm.
Fischer 344 rats were injected intrapleurally with chrysotile and crocidolite asbestos, erionite and attapulgite and observed for their entire lifespan. Detailed analysis of the number per unit mass of the various size categories of the fibers for each mineral species was determined and the dose in terms of actual number of mineral fibers computed. Data for survival time and number of tumors induced suggests that in addition to the length/width factors, an additional property plays a role in fiber potency. Analysis of the available data from the literature, where populations were known to have been exposed to pure mineral fibers, indicates that ranking for human mesothelioma incidence appears congruent with the rat intrapleural data.
"August 1988." Bibliography: p. 8-9.