Record Display for the EPA National Library CatalogRECORD NUMBER: 20 OF 32
|Main Title||Kepone-Induced Scoliosis and Its Histological Consequences in Fish.|
|Author||Couch, John ; Winstead, James ; Goodman., Larry ;|
|CORP Author||Environmental Research Lab., Gulf Breeze, Fla.|
|Stock Number||PB-277 182|
|Additional Subjects||Fishes ; Scoliosis ; Insecticides ; Pesticides ; Toxicology ; Toxic diseases ; Chlorine organic compounds ; Minnows ; Nervous system ; Pathology ; Musculosketal disorders ; Central nervous system ; Histology ; Aquatic animals ; Experimental data ; Reprints ; Kepone ; Laboratory tests|
Scoliosis in fish is caused by several diverse agents that possibly act on the central nervous system, neuromuscular junctions, or ionic metabolism. The organochlorine pesticide Kepone induces scoliosis in the sheepshead minnow. Some effects associated with Kepone-induced scoliosis in these fish are disruption of myotomal patterns, inter- and intramuscular hemorrhage, fractured centra of vertebrae, and death. The histological syndrome of Kepone poisoning in fish and the clinical syndrome in humans suggest that the nervous system is a primary target for Kepone and that scoliosis is a secondary effect of Kepone poisoning in fish.