Main Title |
Comparison of In vivo and In vitro Methods for Assessing the Effects of Bromobenzene on the Hepatic-Metabolizing Enzyme System. |
Author |
Chadwick, R. W. ;
Copeland, M. F. ;
Carlson, G. P. ;
Trela, B. A. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Purdue Univ., Lafayette, IN. School of Pharmacy and Pharmacal Sciences. |
Year Published |
1987 |
Report Number |
EPA/600/J-87/299; |
Stock Number |
PB88-185707 |
Additional Subjects |
Bromo organic compounds ;
Enzymes ;
Liver ;
Chlorobenzenes ;
Rats ;
In vitro analysis ;
In vivo analysis ;
Reprints ;
Bromobenzenes ;
Benzene hexachloride ;
Lindane
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-185707 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
11p |
Abstract |
The effect of daily i.p. injections of 0, 0.05, 0.5 and 5.0 mmol/kg bromobenzene for 1 week on the activity of the hepatic drug-metabolizing enzyme system was measured in the rat by a model substrate assay employing lindane ( -hexachlorocyclohexane) and by a battery of in vitro enzyme assays. The data in the study indicated that repeated pretreatment with bromobenzene for 1 week stimulated a dose-related increase in phase I reactions while inducing phase II reactions at the high dose (5 mmol/kg bromobenzene). The in vivo and in vitro assays showed good agreement. (Copyright (c) Toxicology Letters, Vol. 39, 1987.) |