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Main Title Malaria: Drugs, Disease and Post-genomic Biology [electronic resource] /
Author Compans, R. W.
Other Authors
Author Title of a Work
Cooper, M. D.
Honjo, T.
Koprowski, H.
Melchers, F.
Oldstone, M. B. A.
Olsnes, S.
Potter, M.
Vogt, P. K.
Wagner, H.
Sullivan, David J.
Krishna, Sanjeev.
Publisher Springer Berlin Heidelberg,
Year Published 2005
Call Number QR251-255
ISBN 9783540290889
Subjects Medicine ; Medical parasitology
Internet Access
Description Access URL
Collation XVIII, 340 p. online resource.
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
Drugs and Drug Resistance -- Quinolines and Artemisinin: Chemistry, Biology and History -- Antimalarial Multi-Drug Resistance in Asia: Mechanisms and Assessment -- Antimalarial Drug Resistance in Africa: Strategies for Monitoring and Deterrence -- Malaria the Disease -- Uncomplicated Malaria -- Metabolic Complications of Severe Malaria -- The Clinical and Pathophysiological Features of Malarial Anaemia -- Malaria in the Pregnant Woman -- Biology -- Host Receptors in Malaria Merozoite Invasion -- A Post-genomic View of the Mitochondrion in Malaria Parasites -- The Plastid of Plasmodium spp.: A Target for Inhibitors -- Hemoglobin Degradation -- Bioavailable Iron and Heme Metabolism in Plasmodium falciparum -- Plasmodium Permeomics: Membrane Transport Proteins in the Malaria Parasite -- Plasmodium Ookinete Invasion of the Mosquito Midgut -- Molecular Genetics of Mosquito Resistance to Malaria Parasites -- Functional Proteome and Expression Analysis of Sporozoites and Hepatic Stages of Malaria Development. This volume brings some of the worlds best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two. The opening chapters discuss antimalarials and resistance to them in Africa and Asia. Then there are reviews of the different clinical manifestations of malaria, ranging from uncomplicated infections to severe disease and its complications. This section is followed by detailed reviews of what the new 'omics' offer to investigators of Plasmodium biology and is completed by descriptions of advances in understanding the biology of Plasmodium in the mosquito. If this volume attracts new students and provokes existing investigators to explore new directions, then it will have achieved much of what it has set out to do.