| Main Title |
Interaction between Gamma-Hexachlorocyclohexane and the Gastrointestinal Microflora and Their Effect on the Absorption, Biotransformation, and Excretion of Parathion by the Rat. |
| Author |
Chadwick, R. W. ;
Copeland, M. F. ;
Froehlich, R. ;
Cooke, N. ;
Whitehouse, D. A. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1984 |
| Report Number |
EPA/600/J-84/102; |
| Stock Number |
PB84-246438 |
| Additional Subjects |
Parathion ;
Insecticides ;
Chlorobenzenes ;
Gastrointestinal system ;
Toxicity ;
Laboratory animals ;
Absorption ;
In vivo analysis ;
Environmental surveys ;
Biochemistry ;
Rats ;
Chlorine organic compounds ;
Reprints ;
Lindane ;
Cyclohexane/hexachloro ;
Biotransformation
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-246438 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
Pretreatment of rats with the organochlorine insecticide lindane reduced the estimated absorption rate of parathion from the gastrointestinal tract. Lindane pretreatment also significantly reduced the metabolism of parathion to p-nitrophenol in vivo. Lindane pretreatment altered the gastrointestinal (GI) microflora by increasing the ratio of anaerobes to aerobes. Consistent with this alteration was a significantly greater retention of unaltered parathion and the microbial metabolite aminoparathion in the GI tract of the lindane-pretreated rats 1 h after the administration of parathion. Enhanced conversion of parathion to aminoparathion together with a slower absorption rate may play a role in the antagonism parathion toxicity by lindane. |
