||Preparation of Extrapulmonary Tissues and Body Fluids for Quantitative Transmission Electron Microscope Analysis of Asbestos and Other Mineral Particle Concentrations.
Cook, Philip M. ;
||Environmental Research Lab.-Duluth, MN.
Electron microscopy ;
Body fluids ;
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The preparation of tissue and body fluid samples is a critical step in the determination of microscopic particle concentrations and characteristics by electron microscopy. A critical review of tissue preparation techniques reported in the literature is provided with emphasis on analytical sensitivity and accuracy and the problem of particle contamination. Details of a method devised for analysis of mineral fibers in urine samples are provided as an example of how the basic requirements for insuring quantitative particle analysis are achieved.