Main Title |
Carcinogenicity assessment of chlordane and heptachlor/heptachlor epoxide. |
Author |
Cavender, F. L. ;
Cook, B. T. ;
Page, N. P. ;
Cogliano, V. J. ;
Koppikar, A. M.
|
CORP Author |
United States. Environmental Protection Agency. Carcinogen Assessment Group. |
Publisher |
Carcinogen Assessment Group, Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, |
Year Published |
1986 |
Report Number |
EPA/600/6-87-004 |
Stock Number |
PB87-208757 |
OCLC Number |
16388648 |
Subjects |
Chlordan--Carcinogenicity ;
Heptachlor--Carcinogenicity
|
Additional Subjects |
Carcinogenesis ;
Chlordane ;
Malignant neoplasms ;
Pesticides ;
Toxicity ;
Bioassay ;
Laboratory animals ;
Liver ;
Exposure ;
Epidemiology ;
Chlorinated hydrocarbons ;
Toxic substances ;
Carcinogenesis ;
Cancer ;
CAS 57-74-9 ;
CAS 76-44-8 ;
CAS 1024-57-3 ;
Heptachlor epoxide ;
Heptachlor ;
Occupational safety and health
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EHAM |
RC268.64.C37C3 1986 |
|
Region 1 Library/Boston,MA |
04/29/2016 |
EJED |
EPA 600/6-87-004 |
|
OCSPP Chemical Library/Washington,DC |
01/01/1988 |
EKBD |
EPA-600/6-87-004 |
|
Research Triangle Park Library/RTP, NC |
01/01/1988 |
EKCD |
EPA/600/6-87/004 |
|
CEMM/GEMMD Library/Gulf Breeze,FL |
07/25/2018 |
ELBD ARCHIVE |
EPA 600-6-87-004 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
DISPERSAL |
ERAD |
EPA 600/6-87-004 |
|
Region 9 Library/San Francisco,CA |
09/06/2013 |
ESAD |
EPA 600-6-87-004 |
|
Region 10 Library/Seattle,WA |
03/23/2010 |
NTIS |
PB87-208757 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
1 volume (various pagings) : illustrations ; 28 cm |
Abstract |
Evidence pertaining to the carcinogenicity of chlordane and heptachlor/heptachlor epoxide is reviewed and evaluated. The report covers studies completed before 1985. Case reports and epidemiologic studies of pesticide applicators and pesticide manufacturing workers are reviewed, but because of methodologic limitations, these studies establish neither a positive nor a negative association between cancer and chlordane or heptachlor/heptachlor epoxide exposure. A number of independent studies of laboratory animals, however, demonstrates that chlordane and heptachlor/heptachlor epoxide cause liver cancer in mice and rats. Based on the accumulated evidence, chlordane and heptachlor/heptachlor epoxide are classified as probable human carcinogens, Group B2 using EPA's Guidelines for Carcinogen Risk Assessment. The carcinogenic potency of chlordane and heptachlor/heptachlor epoxide is estimated by fitting mathematical models to the laboratory animal data. These estimates indicate that chlordane and heptachlor/heptachlor epoxide are rather potent carcinogens, ranking in the second quartile of potential carcinogens evaluated by EPA's Carcinogen Assessment Group. A separate mutagenicity assessment of chlordane and heptachlor/heptachlor epoxide is attached as an appendix to the report. The report also includes an extensive list of references pertinent to the carcinogenicity of chlordane and heptachlor/heptachlor epoxide. |
Notes |
Distributed to depository libraries in microfiche. "December 1986." Includes bibliographical references (pages 7-1-7-10). "EPA-600/6-87/004." |