Record Display for the EPA National Library Catalog

RECORD NUMBER: 30 OF 37

Main Title Test Battery for Screening Behavioral Teratogens in Mice.
Author Kallman, M. J. ; Condie, L. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Mississippi Univ., University.
Year Published 1985
Report Number EPA/600/J-85/420;
Stock Number PB86-216199
Additional Subjects Toxicology ; Screening ; Behavior ; Mice ; Laboratory ; Reprints ; Teratogens
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB86-216199 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Abstract
The assessment battery was developed for identifying teratogens in mice (CD-1, outbred strain) since many non-behavioral toxicologists prefer working with the mouse and because the mouse is less costly to house and feed. The approach emphasizes the importance of adult toxicity data in the selection of exposure levels for teratologic studies and for interpreting behavioral teratogen effects. Potential teratogen exposure is both prenatal and postnatal with the goal of identifying the need for more costly and time consuming, cross-fostering and critical period designs. The test battery includes the assessment of multiple behavioral capabilities, including physical landmarks, reflex development, motor capability and passive avoidance learning. The authors have found the behavioral capabilities of the mouse to be similar to those of the rat in variability and range of response. The methdology has emphasized drinking water exposure to chemicals since we were involved in the evaluation of drinking water contaminants but the battery should be amenable to any route of exposure.