Record Display for the EPA National Library Catalog


Main Title Physiological Adaptations to Carbon Monoxide Levels and Exercise in Normal Men.
Author Collie, C. R. ; Workma, J. M. ; Mohle, J. G. ; Aaronso, J. ; Cabul, O. ;
CORP Author University of Southern California, Los Angeles. Dept. of Medicine.
Year Published 1972
Report Number EPA-68-02-0334; RI-72-002;
Stock Number PB-213 834
Additional Subjects ( Humans ; Adaptation) ; ( Air pollution ; Carbon monoxide) ; ( Public health ; Air pollution) ; Exercise(Physiology) ; Males ; Hemoglobins ; Blood ; Stress(Physiology) ; Respiration ; Toxicity ; Oxygen consumption ; Hypoxia ; Carbonylhemoglobin
Library Call Number Additional Info Location Last
NTIS  PB-213 834 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 23p
Normal, young, non-smoking men were studied at rest and during submaximal exercise with carboxyhemoglobin (COHb) levels of about 1% and after breathing CO to raise the COHb level to 8 to 9%. Arterial and mixed venous blood was sampled. CO caused an increase in minute volume and breathing frequency during exercise but not at rest. CO caused no changes in cardiac output, heart rate, lactate, lactate/pyruvate ratio, tidal volume, CO2 output or 2,3 DPG during rest or exercise. CO caused a decrease in O2 consumption, in arterial-venous O2 content difference and in venous O2 content and venous Po2 during exercise and in the latter two also at rest. Changes in O2 affinity are still being calculated.