Record Display for the EPA National Library Catalog


Main Title Identification of Mutagenic Compounds Formed during Chlorination of Humic Acid.
Author Meier, J. R. ; Ringhand, H. P. ; Coleman, W. E. ; Munch, J. W. ; Streicher, R. P. ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1985
Report Number EPA/600/J-85/164;
Stock Number PB86-107232
Additional Subjects Chlorination ; Humic acids ; Mutagens ; Potable water ; Water treatment ; Halogen organic compounds ; Carcinogens ; Public health ; Bioassays ; Water analysis ; Reprints ; Water pollution detection ; Water pollution effects(Humans) ; Halomethanes
Library Call Number Additional Info Location Last
NTIS  PB86-107232 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
Humic acid chlorination products are being studied in an effort to identify the chemicals responsible for the mutagenicity formed during water chlorination. In the present report, nineteen chlorinated organic compounds have been identified and quantified in ether extracts of chlorinated humic acid solutions. Ten of these compounds, including a number of chlorinated propanones and chlorinated propenals, are direct-acting mutagens in the Salmonella/microsome mutagenicity assay. The position of the chlorine substituent has been found to be an important factor in the mutagenic activity of these two classes of compounds. The total mutagenicity of the compounds identified thus far, when tested either individually or as a composite, accounts for only about 8% of the total mutagenicity formed during humic acid chlorination. The addition of bromide to the humic acid chlorination reaction results in up to a two-fold increase in the level of mutagenicity formed.