Record Display for the EPA National Library Catalog


Main Title Biological and Chemical Studies on 3-Chloro-4(Dichloromethyl)-5-Hydroxy-2(5H)-Furanone: A Potent Mutagen in Kraft Pulp Chlorination Effluent and Chlorinated Drinking Water.
Author Ringhand, H. P. ; Meier, J. R. ; Coleman, W. E. ; Schenck, K. M. ; Kaylor, W. H. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1988
Report Number EPA/600/D-88/151;
Stock Number PB88-238126
Additional Subjects Pulp mills ; Mutagens ; Chlorination ; Potable water ; Toxicology ; Oxygen heterocyclic compounds ; Chlorine organic compounds ; Laboratory animals ; Chemical analysis ; Water analysis ; Water pollution ; Waste water ; Toxic substances ; Furanones ; Furanone/chloro-dichloromethyl-hydroxy
Library Call Number Additional Info Location Last
NTIS  PB88-238126 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 26p
The potent bacterial mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) has been identified in the spent bleaching liquors of softwood kraft pulp mills and in drinking waters. In view of the potential hazard to human health and the possible ecological impact from pulp mill discharges, further investigation of the toxicological properties of MX was initiated. Recent studies have shown that MX is a clastogen for cultured Chinese hamster ovary cells and that it is acutely toxic to mice following oral administration or topical exposure with an LD50 of approximately 130 mg/kg for both routes. In order to assess human exposure, the development of a reproducible analytical method for the detection and quantification of MX in water samples was developed.