Record Display for the EPA National Library Catalog


Main Title Influence of Crystallization Habit of Minerals on 'In Vitro' Cytotoxicity.
Author Palekar, Lalita D. ; Spooner, Charles M. ; Coffin, David L. ;
CORP Author Northrop Services, Inc., Research Triangle Park, NC.;GCA Corp., Bedford, MA. GCA Technology Div.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1979
Report Number EPA-68-02-2566 ;EPA-68-02-2771; EPA-600/J-79-136;
Stock Number PB81-240830
Additional Subjects Minerals ; Toxicology ; Cells(Biology) ; Hemolysis ; In vitro analysis ; Erythrocytes ; Reprints ; Cytotoxicity
Library Call Number Additional Info Location Last
NTIS  PB81-240830 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 16p
Four samples of cummingtonite-grunerite series in various crystallization habits were tested in vitro. The cytotoxicity to Chinese hamster ovary cells and hemolysis to sheep erythrocytes was inversely proportional to the structural faults and surface defects of the minerals. At a comparable surface area, asbestiform grunerite (UICC amosite), semi-asbestiform cummingtonite, acicular cummingtonite, and acicular grunerite were found to be cytotoxic and hemolytic in a decreasing order. The influence of particle size on hemolysis and cytotoxicity was observed with acicular grunerite. Although samples of relatively large particle size were found to be inert, samples of smaller particle size were cytotoxic as well as hemolytic. No apparent relationship between surface charge and hemolysis as well as cytotoxicity was observed.