Record Display for the EPA National Library Catalog


Main Title Toxicokinetics and Toxicodynamics of Pyrethroid Insecticides in Fish.
Author Bradbury, S. P. ; Coats, J. R. ;
CORP Author Iowa State Univ., Ames. Dept. of Entomology.;Environmental Research Lab.-Duluth, MN.
Publisher c1989
Year Published 1989
Report Number EPA-R-810659; EPA/600/J-89/032;
Stock Number PB90-100975
Additional Subjects Fishes ; Toxicity ; Insecticides ; Metabolism ; Animal physiology ; Biological effects ; Trout ; Brain ; Reprints ; Pharmacokinetics ; Water pollution effects(Animals) ; Pyrethroids ; Permethrin ; Cypermethrin ; Fenvalerate ; Biotransformation
Library Call Number Additional Info Location Last
NTIS  PB90-100975 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
The pyrethroid insecticides are extremely toxic to fish, with 96-h LC50 values generally below 10 micro g/L and i.p. and i.v. LD50 values below 20 mg/kg. Corresponding LD50 values in mammals and birds are in the range of several hundred to several thousand milligrams per kilogram. The review examines pyrethroid toxicokinetics and toxicodynamics in fish as critical factors associated with species selectivity. Studies with permethrin, cypermethrin and fenvalerate have established that rates of metabolism and elimination in rainbow trout are significantly lower than those reported for birds and mammals. Comparatively low lethal brain pyrethroid concentrations and nonneural aspects of pyrethroid intoxication in fish suggest that variations in toxicodynamics are also crucial in evaluating pyrethroid selectivity.