Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Risk from Exposure to Polychlorinated Dibenzo-p-Dioxins and Dibenzofurans Emitted from Municipal Incinerators.
Author Maukerjee, D. ; Cleverly., D. H. ;
CORP Author Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office.
Publisher c1987
Year Published 1987
Report Number EPA/600/J-87/516;
Stock Number PB90-242363
Additional Subjects Public health ; Incinerators ; Exposure ; Waste disposal ; Toxicity ; Bioassays ; Carcinogens ; Laboratory animals ; Comparison ; Reprints ; Risk assessment ; Air pollution effects(Humans) ; Polychlorinated dibenzodioxins ; Polychlorinated dibenzofurans ; Dibenzodioxin/tetrachloro ; Municipal wastes ; Biological effect ; Air pollution effects(Animals)
Library Call Number Additional Info Location Last
NTIS  PB90-242363 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 12/03/1990
Collation 17p
Incineration of wastes seems to be one of the major sources of PCDDs and PCDFs (dioxins). Their prevalence and extreme stability in the environment, bioavailability and bioaccumulation in the biota and human adipose tissues and breast milk are of much concern. 2,3,7,8-TCDD is one of the most toxic chemicals known and has been found to have teratogenic and carcinogenic activities in animals. Exposure to TCDD can result in chloracne, general weakness, drastic weight loss, hyperpigmentation of skin, hirsutism, porphyria cutanea tarda, liver damage, changes in activities of various liver enzymatic levels, abnormal lipid metabolism, abnormalities of the endocrine and immune systems, and possible teratogenic effects in humans. Moreover, chronic bioassay data indicate that TCDD is one of the most potent carcinogens known. It promotes liver and skin carcinogeneses, and is an initiator for various target organs in rodent test systems. According to the classification system of IARC, the qualitative evidence for carcinogenicity of TCDD is considered to be 'sufficient' in animals and 'inadequate' in humans. Consequently, TCDD has been placed in IARC's 2B category. In the absence of chronic bioassay data on other PCDDs and PCDFs, several TCDD equivalent approaches have been proposed for risk assessment on other congeners or mixtures. The paper compares the various approaches.