Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Assessment of Reproductive Risks (Journal Version).
Author Clegg, E. D. ; Sakai, C. S. ; Voytek, P. E. ;
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher 1985
Year Published 1985
Report Number EPA/600/J-85/501;
Stock Number PB89-134746
Additional Subjects Pesticides ; Toxicology ; Reproduction(Biology) ; Hazardous materials ; Teratogens ; Laboratory animals ; Humans ; Males ; Females ; Regulations ; Tests ; Concentration(Composition) ; Exposure ; Methodology ; Reprints ; Risk assessment
Library Call Number Additional Info Location Last
NTIS  PB89-134746 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/08/1989
Collation 14p
In the regulatory process, the hazards posed by potentially toxic agents to the female and male reproductive systems and to developing young are evaluated by risk assessment procedures. In the paper, toxicity testing and the regulatory process are discussed, with emphasis on risk assessment. The suggested testing protocols of the Pesticide Assessment Guidelines (U.S. EPA) are presented as an example of testing that might be done to produce toxicity data for an agent. Protocols and end points that are utilized in testing for reproductive effects are described. Included are acute, subchronic, chronic, and short-term tests. The four components of reproductive risk assessment (hazard identification, dose-response assessment, exposure assessment, and risk characterization) are examined. Effects of dibromochloropropane on rabbit testicular parameters are used to demonstrate approaches that could be taken in doing a reproductive risk assessment. Research needs are identified. Areas in which changes in reproductive risk assessment are anticipated, as well as the mechanism for influencing the nature and extent of those changes are discussed.