Record Display for the EPA National Library Catalog

RECORD NUMBER: 22 OF 24

Main Title Primer on the Ames 'Salmonella typhimurium' Assay for Mutagenicity.
Author Claxton, Larry D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-600/D-83-058;
Stock Number PB83-219634
Additional Subjects Salmonella typhimurium ; Deoxyribonucleic acids ; Toxicology ; Bacteria ; Bioassay ; Genes ; Mutations ; Tests ; Ames test ; Mutagenesis ; Genotoxicity
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB83-219634 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 19p
Abstract
Since interaction with deoxyribonucleic acid (DNA) defines the genotoxic end points detected, simple in vitro tests can be used to monitor or screen most chemicals or mixtures of chemicals for specific genotoxic activity. Bacterial tests to screen classes of chemicals for gene mutations can provide a screen for many potential mutagens, carcinogens, and teratogens. Since the biochemical mechanisms for all mutagens, carcinogens, and teratogens are not the same, however, bacterial tests cannot be expected to detect all genotoxicants. Only by clearly understanding a test's usages and limits, can one most effectively use the information provided by that test.