Record Display for the EPA National Library Catalog


Main Title Design and Implementation of a Collaborative Study of the Mutagenicity of Complex Mixtures in 'Salmonella typhimurium'.
Author Lewtas, J. ; Claxton, L. D. ; Rosenkranz, H. S. ; Schuetzle, D. ; Shelby, M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Pittsburgh Univ., PA. Dept. of Environmental and Occupational Health. ;Ford Motor Co., Dearborn, MI. Scientific and Research Lab. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. ;National Inst. of Public Health, Tokyo (Japan).
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/055;
Stock Number PB92-150697
Additional Subjects Salmonella typhimurium ; Toxic substances ; Mutagens ; Mixtures ; Air pollutants ; Mutagenicity tests ; Bioassay ; Aromatic polycyclic hydrocarbons ; Coal tar ; Interlaboratory comparisons ; Reprints ; Standard Reference Materials
Library Call Number Additional Info Location Last
NTIS  PB92-150697 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
An international collaborative study of the mutagenicity of complex environmental mixtures in the Ames Salmonella typhimurium mutation assay was performed. The objectives of the study were: (1) to estimate the inter and intra-laboratory variability associated with the extraction of mixtures for bioassay, (2) to estimate the inter and intra-laboratory variability associated with the Salmonella typhimurium bioassay when applied to complex mixtures, (3) to determine if mutagenicity values can be determined from this collaborative study for issuance with standard reference complex mixtures. The complex mixtures used in the study were selected from standard reference materials (SRMs) which had previously been issued by the U.S. NIST as SRMs 1597 (coal tar), SRMs 1649 (diesel particulate matter) and SRMs 1650 (urban air particulate matter) with certified values for polycyclic aromatic hydrocarbons.