||Induction, Accumulation, and Persistence of Sister Chromatid Exchanges in Women with Breast Cancer Receiving Cyclophosphamide, Adriamycin, and 5-Fluorouracil Chemotherapy.
Tucker, J. D. ;
Wyrobek, A. J. ;
Ashworth, L. K. ;
Christensen, M. L. ;
Burton., G. V. ;
||Lawrence Livermore National Lab., CA. Biomedical Sciences Div. ;Duke Univ. Medical Center, Durham, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. Epidemiology Branch.;Health Effects Research Lab., Research Triangle Park, NC.
Antineoplastic agents ;
Breast neoplasma ;
Sister chromatid exchange ;
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The induction, stimulation, and persistence of sister chromatid exchanges (SCE's) and high SCE frequency cells (HFC's) was measured in peripheral lymphocytes of women with breast cancer before chemotherapy and on multiple occasions during and after therapy. Chemotherapy consisted of i.v. infusion of cyclophosphamide, Adriamycin, and 5-fluorouracil, administered on day 1 of each of approximately six 21-day cycles. This treatment resulted in a highly significant of SCE's (1.8-fold, P < 0.0001) and HFC's (5-fold, P < 0.0001) measured in samples obtained 1 week after the first therapy. Accumulation of lesions leading to SCE's was measured by comparing samples surrounding the first and last rounds of therapy and was significant for both SCE's and HFC's in most comparisons. Persistence of lesions leading to SCE's was evaluated at multiple times until 9 months after completion of therapy, and both SCE's and HFC's remained significantly elevated throughout this time.