||Measurements of Conformational Changes during Adhesion of Lipid and Protein (Polylysine and S-Layer) Surfaces.
Leckband, D. ;
Chen, Y. L. ;
Israelachvili, J. ;
Wickman, H. H. ;
Fletcher, M. ;
||California Univ., Santa Barbara. ;Maryland Univ., Baltimore. Center for Biotechnology. ;National Science Foundation, Washington, DC.;Corvallis Environmental Research Lab., OR.
Surface properties ;
Molecular conformation ;
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The adhesion forces between various surfaces were measured using the 'surface forces apparatus' technique. This technique allows for the thickness of surface layers and the adhesion force between them to be directly measured in controlled vapor or liquid environments. Three types of biological surfaces were prepared by depositing various lipid-protein monolayers (with thicknesses ranging from 1 to 4 nm) on the inert, molecularly smooth mica surface: (i) hydrophobic lipid monolayers; (ii) amphiphilic polyelectrolyte surfaces of adsorbed polylysine; and (iii) deposited bacterial S-layer proteins. The adhesion, swelling, and wetting properties of these surfaces was measured as a function of relative humidity and time. (Copyright (c) 1993 John Wiley & Sons, Inc.)