Record Display for the EPA National Library Catalog


Main Title Hepatocarcinogenicity of Benzo(a)Pyrene to Rainbow Trout By Dietary Exposure and Intraperitoneal Injection.
Author Hendricks, J. D. ; Meyers, T. R. ; Shelton, D. W. ; Casteel, J. L. ; Bailey, G. S. ;
CORP Author Oregon State Univ., Corvallis. Dept. of Food Science and Technology. ;Oregon State Univ., Corvallis. Agricultural Experiment Station.;Environmental Research Lab., Gulf Breeze, FL.
Year Published 1985
Report Number EPA/600/J-85/053;
Stock Number PB85-210110
Additional Subjects Pyrenes ; Trout ; Carcinogens ; Diets ; Benzene ; Aromatic polycyclic hydrocarbons ; Liver ; Neoplasms ; Histology ; Tolerances(Physiology) ; Growth ; Mortality ; Enzymes ; Reprints ; Salmo gairdneri ; BP ; Pyrene/benzo
Library Call Number Additional Info Location Last
NTIS  PB85-210110 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
The influence of benzo(a)pyrene on the induction of certain enzymes within the hepataic mixed-function oxidase (MFO) system and its potential carcinogenicity were examined in rainbow trout (Salmo gairdneri). Twelve months after BP exposure was initiated, 15% of the BP-fed fish had histologically confirmed neoplasms of the liver. After 18 months the incidence increased to 25%. No evidence of neoplasia was observed in control fish. These results indicate that BP is a potent inducer of selected hepatic MFO enzymes and establish, for the first time, the hepatocarcinogenicity of BP in an aquatic species.